Marburg virus: CDC warns US public health officials of Ebola-like disease

The U.S. Centers for Disease Control and Prevention (CDC) published a warning about the rare Ebola-like Marburg virus Thursday, advising American public health officials and doctors to be on the lookout.

There are two confirmed outbreaks of Marburg virus disease (MVD) in Tanzania and Equatorial Guinea. The CDC says the pathogen likely spilled over from wild animals to humans.

There have been no reported Marburg diagnoses in the U.S., but the CDC seeks to “increase awareness of the risk of imported cases in the United States.” 

The disease is usually spread through contact with infected blood or other bodily fluids rather than airborne transmission.

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Electron Micrograph Of The Marburg Virus. Marburg Virus, First Recognized In 1967, Causes A Sever Type Of Hemorrhagic Fever, Which Affects Humans, As Well As Non Human Primates.

“Currently, the risk of MVD in the United States is low; however, clinicians should be aware of the potential for imported cases,” the CDC said.

The disease has epidemic potential, according to the World Health Organization (WHO). It has high fatality rates — out of eight Tanzanian cases reported so far, five of the patients died.

Equatorial Guinea officials reported their first outbreak Feb. 13, where there have been 14 confirmed cases and 10 deaths. The Tanzanian government announced its first-ever outbreak of MVD on March 21.

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This transmission electron micrograph (TEM) revealed some of the ultrastructural morphology exhibited by the Marburg virus, the cause of Marburg hemorrhagic fever. 

Symptoms include headache, fatigue, sudden fever, unexplained bleeding and gastrointestinal symptoms. Muscle and joint pain and loss of appetite are also common.

The incubation period is usually two to 21 days. The CDC noted that the disease is sometimes difficult to diagnose.

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“Many of the signs and symptoms of MVD are similar to other infectious diseases (such as malaria or typhoid fever) or viral hemorrhagic fevers that may be endemic in the area (such as Lassa fever or Ebola),” the CDC said. “This is especially true if only a single case is involved.”

Equatorial Guinea officials reported their first outbreak on February 13, where have been 14 confirmed cases and 10 deaths. (Center of Disease Control)

The CDC says the disease’s mortality rate is anywhere from 23% to 90%. There is no Food and Drug Administration (FDA) approved vaccine for the disease, but fluid replacement and intensive supportive care in its early stages can be successful.